東海大学における軟骨再生医療

発表論文
2020-2011

2020

再生医療, 19(2), 142-148, 2020.

細胞シートによる関節軟骨の再生医療 -臨床研究・先進医療-.

佐藤正人

2020

Regenerative Therapy, 14, 215-221, 2020.

Development of an efficient vitrification method for chondrocytesheets for clinical application.

Hayashi A, Maehara M, Uchikura A, Matsunari H, Matsumura K, Suong-Hyu H, Sato M

2020

J Tissue Eng Regen Med, [Epub ahead of print] 2020.

Regenerative effects of human chondrocyte sheets in a xenogeneic transplantation model using immune‐deficient rats.

Takizawa D, Sato M, Okada E, Takahashi T, Maehara M, Tominaga A, Sogo Y, Toyoda E, Watanabe M

2020

関節外科基礎と臨床, 39(9), 956-961, 2020.

自己蛋白質溶液.

和才志帆, 前原美樹, 内山綾香, 岡田恵里, 渡辺雅彦, 佐藤正人

2020

Scientific Reports, 10:10572, 2020.

Characteristics of autologous protein solution and leucocytepoor platelet-rich plasma for the treatment of osteoarthritis of the knee.

Wasai S, Sato M, Maehara M, Toyoda E, Uchiyama R, Takahashi T, Okada E, Iwasaki Y, Suzuki S, Watanabe M

2020

Bone Joint Nerve, 10(2), 193-196, 2020.

変形性膝関節症に対する多血小板血漿（PRP）治療：自験例に基づく基礎と臨床.

和才志帆, 佐藤正人, 前原美樹, 内山綾香, 渡辺雅彦

2020

再生医療, 19(1), 11, 2020.

「アンメットメディカルニーズに応える」とは？

佐藤正人

2020

臨床スポーツ医学, 37(1), 2020.

再生医療の現状とスポーツ医学への応用.

佐藤正人

2020

2019

International Journal of Moleculer Sciences, 21(1):E149, 2019.

Transcriptomic and Proteomic Analyses Reveal the Potential Mode of Action of Chondrocyte Sheets in Hyaline Cartilage Regeneration.

Toyoda E, Sato M, Takahashi T, Maehara M, Okada E, Wasai S, Iijima H, Nonaka K, Kawaguchi Y, Watanabe M

2019

NPJ Regen Med, 4, 4, 2019.

Combined surgery and chondrocyte cell-sheet transplantation improves clinical and structural outcomes in knee osteoarthritis.

Sato M, Yamato M, Mitani G, Takagaki T, Hamahashi K, Nakamura Y, Ishihara M, Matoba R, Kobayashi H, Okano T, Mochida J, Watanabe M

2019

別冊整形外科, 76, 98-103, 2019.

変形性膝関節症に対する多血小板血漿療法.

和才志帆, 佐藤正人, 前原美樹, 渡辺雅彦

2019

Regenerative Therapy, 10, 17-26, 2019.

Multilineage-differentiating stress-enduring (Muse)-like cells exist in synovial tissue.

Toyoda E, Sato M, Takahashi T, Maehara M, Nakamura Y, Mitani G, Takagaki T, Hamahashi K, Watanabe M

2019

2018

Regenerative Therapy, 9, 24-31, 2018.

Cartilage repair and inhibition of the progression of cartilage degeneration after transplantation of allogeneic chondrocyte sheets in a nontraumatic early arthritis model.

Takatori N, Sato M, Toyoda E, Takahashi T, Okada E, Maehara M, Watanabe M

2018

THE BONE, 32(1), 109-112, 2018.

早期KOAに対する軟骨細胞シートの可能性.

浜橋恒介, 佐藤正人, 三谷玄弥, 高垣智紀, 芹ヶ野健司, 横山美由希, 谷良樹, 渡辺雅彦

2018

膜, 43 (2), 50-55, 2018.

細胞シートによる関節軟骨再生医療とガラス化保存技術の開発.

前原美樹, 豊田恵利子, 高橋匠, 佐藤正人

2018

Biochem Biophys Res Commun, 496(2), 429-435, 2018.

Quality assessment of cellular and tissue-based products using liquid chromatography-tandem mass spectrometry.

Tominaga A, Sato M, Takahashi T, Toyoda E, Toyoda K, Suzuki T, Takahashi M, Watanabe M, Okazaki K

2018

杏子（秦野伊勢原医師会広報）, 46(12), 188-190, 2018.

東海大学で実施している軟骨再生医療（臨床研究）について.

佐藤正人

2018

J Tissue Eng Regen Med, [Epub ahead of print] 2018.

Intra-articular administration of EP2 enhances the articular cartilage repair in a rabbit model.

Tani Y, Sato M, Yokoyama M, Yokoyama M, Takahashi T, Toyoda E, Okada E, Fujimura S, Maruki H, Kato Y, Yamato M, Okano T, Mochida J

2018

J Tissue Eng Regen Med, 12, 2067-2076, 2018.

Rabbit xenogeneic transplantation model for evaluating human chondrocyte sheets used in articular cartilage repair.

Takahashi T, Sato M, Toyoda E, Maehara M, Takizawa D, Maruki H, Tominaga A, Okada E, Okazaki K, Watanabe M

2018

2017

Inflamm Regen, 37:22, 2017.

Characterization of polydactyly-derived chondrocyte sheets versus adult chondrocyte sheets for articular cartilage repair.

Maehara M, Sato M, Toyoda E, Takahashi T, OkadaE, Kotoku T, Watanabe M

2017

J Biomed Mater Res B Appl Biomater, 105(8), 2592-2602, 2017.

Effects of a cell-free method using collagen vitrigel incorporating TGF-β1 on articular cartilage repair in a rabbit osteochondral defect model.

Maruki H, Sato M, Takezawa T, Tani Y, Yokoyama M, Takahashi T, Toyoda E, Okada E, Aoki S, Mochida J, Kato Y

2017

日本整形外科学会誌（J.Jpn.Orthop.Assoc）, 91, 217-222, 2017.

自己および同種細胞シートによる関節軟骨再生医療と再生医療新法への対応.

佐藤正人

2017

分子リウマチ治療, 10(2), 24-27, 2017.

同種軟骨細胞シートによるOA治療の可能性.

浜橋恒介, 佐藤正人, 三谷玄弥, 高垣智紀, 横山美由紀, 谷良樹, 豊田恵利子, 渡辺雅彦

2017

Progress in medicine 基礎・治療, 37(5), 55-59, 2017.

細胞シートによる関節軟骨再生治療.

佐藤正人

2017

J Tissue Eng Regen Med, 11(12), 3437-3444, 2017.

The effects of using vitrified chondrocyte sheets on pain alleviation and articular cartilage repair.

Tani Y, Sato M, Maehara M, Nagashima H, Yokoyama M, Yokoyama M, Yamato M, Okano T, Mochida J

2017

J Tissue Eng Regen Med, 11(10), 2885-2894, 2017.

Characterization of layered chondrocyte sheets created in a co-culturesystem with synoviocytes in a hypoxic environment.

Kokubo M, Sato M, Yamato M, Mitani G, Uchiyama Y, Mochida J, Okano T

2017

J Tissue Eng Regen Med, 11(12), 3305-3312, 2017.

Platelet-activated serum might have a therapeutic effect on damaged articular cartilage.

Yokoyama M, Sato M, Tani Y, Yokoyama M, Kokubo M, Yamato M, Okano T, Mochida J

2017

関節外科基礎と臨床, 36(12), 1212-1217, 2017.

関節軟骨再生の臨床応用を踏まえた前臨床研究におけるエビデンス構築‐動物モデル選択‐.

高橋匠, 佐藤正人

2017

2016

Stem Cell Research & Therapeutics, 1(1), 2016.

Application of chondrocyte sheet for cartilage regeneration.

Toyoda E, Sato M, Takahashi T, Maehara M, Mochida J

2016

Bone Joint Nerve, 6(3), 589-594, 2016.

膝OAに対するVEGF阻害剤の効果.

長井敏洋, 佐藤正人

2016

2015

Tissue Engineering part C Methods, 22(1), 59-68, 2015.

Assessment of the Safety of Chondrocyte Sheet Implantation for Cartilage Regeneration.

Yokoyama M, Sato M, Mitani G, Takagaki T, Yokoyama M, Okada E, Kokubo M, Yamato M, Ito N, Takaku Y, Murai K, Matoba R, Akutsu H, Yamato M, Okano T, Mochida J

2015

日本臨牀, 73(増刊号5, 再生医療‐新たな医療を求めて‐), 504-508, 2015.

細胞シートによる関節治療を目指したヒト幹細胞臨床研究.

豊田恵利子, 佐藤正人, 持田譲治

2015

月刊細胞‐The Cell‐, 47(8)臨時増刊号, 14-17, 2015.

変形性膝関節症の軟骨再生治療.

佐藤正人

2015

関節外科 34(5), 58-61, 2015.

温度応答性培養皿を用いて作製した軟骨細胞シートの関節軟骨再生効果.

浜橋恒介, 佐藤正人, 高垣智紀,　三谷玄弥, 持田譲治

2015

International Journal of Biological & Pharmaceutical Research 6, 351-358, 2015.

Interactions between jellyfish mucin and hyaluronan in human chondrocytes.

Takagaki T, Sato M, Kawake T, Baba T, Kihira K, Mochida J

2015

Arthritis Research & Therapy, 17:383, 2015.

Usefulness of using laser-induced photoacoustic measurement and 3.0 Tesla MRI to assess knee cartilage damage: a comparison study.

Ukai T , Sato M, Ishihara M , Yokoyama M, Takagaki T , Mitani G, Tani Y, Yamashita T, Imai Y, Mochida J

2015

BMC Musculoskeletal Disorders 16:35, 2015.

Diffusion tensor imaging can detect the early stages of cartilage damage: a comparison study.

Ukai T, Sato M, Yamashita T, Imai Y, Mitani G, Takagaki T, Serigano K, Mochida J

2015

2014

整形外科 65(10), 1034, 2014.

【誌説】実験ノート.

佐藤正人

2014

最新医学 69(7月増刊号), 144-153, 2014.

セルシートエンジニアリング, 関節軟骨再生.

佐藤正人

2014

日本臨牀 72(増刊号3), 722-727, 2014.

細胞シートによる関節治療の再生医療.

佐藤正人

2014

The Anatomical Record 297（1）, 36-43, 2014.

Articular cartilage regeneration using cell sheet technology.

Sato M, Yamato M, Hamahashi K, Okano T, Mochida J

2014

日本再生医療学会誌 13(1), 64-68, 2014.

関節治療を加速する細胞シートによる再生医療の実現.

佐藤正人

2014

日本機械学会誌 117(1142), 16-19, 2014.

軟骨再生医療の現状・今後の展望.

佐藤正人

2014

Biomaterials 35(7) 2199-2206, 2014.

In vivo cell tracking by bioluminescence imaging after transplantation of bioengineered cell sheets to the knee joint

Takaku Y, Murai K, Ukai T, Ito S, Kokubo M, Satoh M, Kobayashi E, Yamato M, Okano T, Takeuchi M, Mochida J, Sato M

2014

J Biomed Mater Res A, 102(9), 2927-2933, 2014.

Potential utility of cell sheets derived from the anterior cruciate ligament and synovium fabricated in temperature-responsive culture dishes.

Mitani G, Sato M, Yamato M, Kokubo M, Takagaki T, Ebihara G, Okano T, Mochida J

2014

Arthritis Research & Therapy 16(5): 427, 2014.

Bevacizumab, an anti-vascular endothelial growth factor antibody, inhibits osteoarthritis.

Nagai T, Sato M, Kobayashi M, Yokoyama M, Tani Y, Mochida J

2014

The BONE 28(2), 105-110, 2014.

骨・軟骨イメージング（光音響を用いて）.

石原美弥, 佐藤正人

2014

2013

CLINICAL CALCIUM 23(12), 59-65, 2013.

細胞シートによる関節軟骨の治療.

佐藤正人

2013

BMC Biotechnol 13(58), 2013.

Development of a novel vitrification method for chondrocyte sheets.

Maehara M, Sato M, Watanabe M, Matsunari H, Kokubo M, Kanai T, Sato M, Matsumura K,Hyon SH, Yokoyama M, Mochida J, Nagashima H

2013

Pharma Medica 31(4), 15-19, 2013.

細胞シートによる関節軟骨再生治療.

佐藤正人

2013

整形・災害外科 56(5), 565-572. 2013.

細胞シート技術を応用した軟骨再生法の開発

佐藤正人, 持田讓治

2013

J Tissue Eng Regen Med, Published online 2013, 10(6), 486-495, 2013.

Characterization of chondrocyte sheets prepared using a co-culture method with temperature-responsive culture inserts.

Kokubo M, Sato M, Yamato M, Mitani G, Kutsuna T, Ebihara G, Okano T, Mochida J

2013

整形外科 64(5), 468, 2013.

血管新生阻害剤‐その適応の拡大をめざして.

長井敏洋, 佐藤正人, 持田讓治

2013

2012

J Tissue Eng Regen Med, 9(1), 24-30, 2012.

Studies of the humoral factors produced by layered chondrocyte sheets.

Hamahashi K, Sato M, Yamato M, Kokubo M, Mitani G, Ito S, Nagai T, Ebihara G, Kutsuna T, Okano T, Mochida J

2012

Biomaterials 33(21), 5278-5286, 2012.

Repair of articular cartilage defect with layered chondrocyte sheets and cultured synovial cells.

Ito S, Sato M, Yamato M, Mitani G, Kutsuna T, Nagai T, Ukai T, Kobayashi M, Kokubo M, Okano T, Mochida J

2012

Biomaterials 33(15), 3846-3851, 2012.

Cartilage repair in transplanted scaffold-free chondrocyte sheets using a minipig model.

Ebihara G, Sato M, Yamato M, Mitani G, Kutsuna T, Nagai T, Ito S, Ukai T, Kobayashi M, Kokubo M, Okano T, Mochida J

2012

臨床整形外科 47(1), 27-31, 2012.

ラット膝関節内へ移植した細胞シートのBioluminescenceによる経時的評価.

高久裕子, 村井邦彦, 鵜養拓, 伊藤聡, 小久保舞美, 小林英司, 竹内護, 持田讓治, 佐藤正人

2012

Journal of Orthopaedic Research 30(12), 1915-1922, 2012.

MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism.

Ukai T, Sato M, Akutsu H, Umezawa A, Mochida J

2012

BMC Musculoskeletal Disorders 13(1):51, 2012.

Human telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential.

Sato M, Shin-ya K, Lee JI, Ishihara M, Nagai T, Kaneshiro N, Mitani G, Tahara H, Mochida J

2012

整形外科 63(9), 980, 2012.

【総説】ナノ秒パルスレーザー.

佐藤正人

2012

O plus E 34(2), 139-144, 2012.

レーザー・光技術の整形外科領域への応用と展望.

佐藤正人, 石原美弥, 菊地眞, 持田讓治

2012

2011

リウマチ科 46(4), 406-414, 2011.

抗VEGFヒト化モノクローナル抗体投与による関節軟骨修復.

長井敏洋, 佐藤正人, 持田讓治

2011

European Cells and Materials 22, 275-290, 2011.

Transplantation of scaffold-free spheroids composed of synovium-derived cells and chondrocytes for the treatment of cartilage defects of the knee.

Lee JI, Sato M, Kim HW, Mochida J

2011

整形外科 62(6), 550, 2011.

【総説】関節軟骨の修復・再生における組織工学的軟骨の役割.

佐藤正人

2011

整形・災害外科 54(7), 839-843, 2011.

【総説】ナノ秒パルスレーザーによる鏡視下関節軟骨の機能評価.

佐藤正人, 石原美弥, 三谷玄弥, 沓名寿治, 菊地眞, 持田讓治

2011

Lasers in Surgery and Medicine 43(5), 421-432, 2011.

A diagnostic system for articular cartilage using non-destructive pulsed laser irradiation.

Sato M, Ishihara M, Kikuchi M, Mochida J

2011

HUMAN SCIENCE 22(2), 13-17, 2011.

【総説】関節軟骨を機能に基づいて正しく評価するために.

佐藤正人

2011

BMC Biotechnology, 11:19, 2011.

Measurement of diffusion in articular cartilage using fluorescence correlation spectroscopy.

Lee JI, Sato M, Ushida K, Mochida J

2011

東海大学における軟骨再生医療

発表論文 2020-2011

2020

細胞シートによる関節軟骨の再生医療 -臨床研究・先進医療-.

Development of an efficient vitrification method for chondrocytesheets for clinical application.

Regenerative effects of human chondrocyte sheets in a xenogeneic transplantation model using immune‐deficient rats.

自己蛋白質溶液.

Characteristics of autologous protein solution and leucocytepoor platelet-rich plasma for the treatment of osteoarthritis of the knee.

変形性膝関節症に対する多血小板血漿（PRP）治療：自験例に基づく基礎と臨床.

「アンメットメディカルニーズに応える」とは？

再生医療の現状とスポーツ医学への応用.

2019

Transcriptomic and Proteomic Analyses Reveal the Potential Mode of Action of Chondrocyte Sheets in Hyaline Cartilage Regeneration.

Combined surgery and chondrocyte cell-sheet transplantation improves clinical and structural outcomes in knee osteoarthritis.

変形性膝関節症に対する多血小板血漿療法.

Multilineage-differentiating stress-enduring (Muse)-like cells exist in synovial tissue.

2018

Cartilage repair and inhibition of the progression of cartilage degeneration after transplantation of allogeneic chondrocyte sheets in a nontraumatic early arthritis model.

早期KOAに対する軟骨細胞シートの可能性.

細胞シートによる関節軟骨再生医療とガラス化保存技術の開発.

Quality assessment of cellular and tissue-based products using liquid chromatography-tandem mass spectrometry.

東海大学で実施している軟骨再生医療（臨床研究）について.

Intra-articular administration of EP2 enhances the articular cartilage repair in a rabbit model.

Rabbit xenogeneic transplantation model for evaluating human chondrocyte sheets used in articular cartilage repair.

2017

Characterization of polydactyly-derived chondrocyte sheets versus adult chondrocyte sheets for articular cartilage repair.

Effects of a cell-free method using collagen vitrigel incorporating TGF-β1 on articular cartilage repair in a rabbit osteochondral defect model.

自己および同種細胞シートによる関節軟骨再生医療と再生医療新法への対応.

同種軟骨細胞シートによるOA治療の可能性.

細胞シートによる関節軟骨再生治療.

The effects of using vitrified chondrocyte sheets on pain alleviation and articular cartilage repair.

Characterization of layered chondrocyte sheets created in a co-culturesystem with synoviocytes in a hypoxic environment.

Platelet-activated serum might have a therapeutic effect on damaged articular cartilage.

関節軟骨再生の臨床応用を踏まえた前臨床研究におけるエビデンス構築‐動物モデル選択‐.

2016

Application of chondrocyte sheet for cartilage regeneration.

膝OAに対するVEGF阻害剤の効果.

2015

Assessment of the Safety of Chondrocyte Sheet Implantation for Cartilage Regeneration.

細胞シートによる関節治療を目指したヒト幹細胞臨床研究.

変形性膝関節症の軟骨再生治療.

温度応答性培養皿を用いて作製した軟骨細胞シートの関節軟骨再生効果.

Interactions between jellyfish mucin and hyaluronan in human chondrocytes.

Usefulness of using laser-induced photoacoustic measurement and 3.0 Tesla MRI to assess knee cartilage damage: a comparison study.

Diffusion tensor imaging can detect the early stages of cartilage damage: a comparison study.

2014

【誌説】実験ノート.

セルシートエンジニアリング, 関節軟骨再生.

細胞シートによる関節治療の再生医療.

Articular cartilage regeneration using cell sheet technology.

関節治療を加速する細胞シートによる再生医療の実現.

軟骨再生医療の現状・今後の展望.

In vivo cell tracking by bioluminescence imaging after transplantation of bioengineered cell sheets to the knee joint

Potential utility of cell sheets derived from the anterior cruciate ligament and synovium fabricated in temperature-responsive culture dishes.

Bevacizumab, an anti-vascular endothelial growth factor antibody, inhibits osteoarthritis.

骨・軟骨イメージング（光音響を用いて）.

2013

細胞シートによる関節軟骨の治療.

Development of a novel vitrification method for chondrocyte sheets.

細胞シートによる関節軟骨再生治療.

細胞シート技術を応用した軟骨再生法の開発

Characterization of chondrocyte sheets prepared using a co-culture method with temperature-responsive culture inserts.

血管新生阻害剤‐その適応の拡大をめざして.

2012

Studies of the humoral factors produced by layered chondrocyte sheets.

Repair of articular cartilage defect with layered chondrocyte sheets and cultured synovial cells.

Cartilage repair in transplanted scaffold-free chondrocyte sheets using a minipig model.

ラット膝関節内へ移植した細胞シートのBioluminescenceによる経時的評価.

MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism.

Human telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential.

【総説】ナノ秒パルスレーザー.

レーザー・光技術の整形外科領域への応用と展望.

2011

抗VEGFヒト化モノクローナル抗体投与による関節軟骨修復.

Transplantation of scaffold-free spheroids composed of synovium-derived cells and chondrocytes for the treatment of cartilage defects of the knee.

【総説】関節軟骨の修復・再生における組織工学的軟骨の役割.

【総説】ナノ秒パルスレーザーによる鏡視下関節軟骨の機能評価.

A diagnostic system for articular cartilage using non-destructive pulsed laser irradiation.

【総説】関節軟骨を機能に基づいて正しく評価するために.

Measurement of diffusion in articular cartilage using fluorescence correlation spectroscopy.

発表論文
2020-2011