txt_head

Project

Research objectives

Our main objective is in the realization of regenerative medicine using chondrocyte sheets for the treatment of articular cartilage defects associated with degenerative diseases (such as osteoarthritis of the knee). The clinical study using autologous cells (patients’ own cells) was conducted with the approval from the Ministry of Health, Labour and Welfare of Japan. All patients in the clinical study for the transplantation of autologous chondrocyte sheets have reported favorable progress, and we are in preparations to apply for Advanced Medical Care. Furthermore, another clinical study using allogeneic cells (other donor cells) was submitted for approval as a provision plan for Class I Regenerative medicine under the title “Realization of regenerative medicine through allogeneic chondrocyte sheets for the treatment of osteoarthritis of the knee” to the Ministry of Health, Labour and Welfare of Japan, and after acceptance, the treatment of the first patient was conducted in February of 2017. We will work to conduct the safety evaluations without delay and while preparing and establishing the peripheral environment for allogeneic transplantations, we hope to translate this research to industry-driven clinical trials.

Research Project for Practical Applications of Regenerative Medicine under the Japan Agency for Medical Research and Development (AMED)
“Realization of regenerative medicine through allogeneic chondrocyte sheets for the treatment of osteoarthritis of the knee”

Under this grant program, we aim to complete the treatment of ten patients (eight patients remaining) as approved in our provision plan for Class I Regenerative medicine conforming to the new 2014 Act on the Safety of Regenerative Medicine. Our goals are to confirm safety through the clinical study and to also evaluate and verify efficacy of allogeneic chondrocyte sheets.

Project Focused on Developing Key Evaluation Technology: Evaluation for Industrialization in the Field of Regenerative Medicine under AMED
“Development of the evaluation methods for the efficacy of allogenic chondrocyte sheets”

Under this grant program, we are building upon the results obtained from establishing a platform for gene expression analysis from small samples obtained during the clinical study using autologous chondrocyte sheets and identifying potential gene marker sets that indicate clinical effectiveness. We aim to use such knowledge to develop similar technologies for allogeneic chondrocyte sheets and apply the current database to develop a method to evaluate safety and efficacy for industrialization.

page top

Our reseach was introduced on a news program in Taiwan

Our research was introduced on NHK World TV

UMIN CTR